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Five of these participants withdrew because of scheduling issues, and two subjects opted to leave the trial for unspecificpersonal reasons. Fasting: The history, pathophysiology and complications. Affecting 47 million Americans 2, it is associated with a major increase in the risk of cardiovascular disease CVD and all-cause mortality 3. Water-only fasting only water is permitted, plus salt and micronutrients. The metabolic syndrome consists of a combination of abdominal obesity, insulin resistance, hypertension, and dyslipidemia [ 72 ]. Anson R. Todd E. See other articles in PMC that cite the published article. Systolic blood pressure mmHg. Life Sci. McCue M.